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Adoption of the European Charter for Researchers and

the Code of Conduct for the Recruitment of Researchers

On 28.Aug.2024, the Institute of Cellular Biology and Pathology "Nicolae Simionescu" received the Diploma of Excellence for Human Resources in Research from the European Commission.

Details here:

https://www.icbp.ro/static/en/en-careers/otmr_strategy_hrs4r.html

Published papers

Loredan S. Niculescu and Dimitris Kardassis, Chapter 8. Bridging the Gap in Transcriptomics: From Animal to Human Studies in Atherosclerosis, Book chapter in: Transcriptomics in Atherosclerosis: Deciphering Molecular Signatures and Advancing Therapeutic Strategies, Imprint: Elsevier, Editors: Yvan Devaux, Miron Sopić, Paperback ISBN: 9780443330643, eBook ISBN: 9780443330650, 2025.
Dimitris Kardassis, Cécile Vindis, Camelia Sorina Stancu, Laura Toma, Anca Violeta Gafencu, Adriana Georgescu, Nicoleta Alexandru-Moise, Filippo Molica, Brenda R. Kwak, Alexandrina Burlacu, Ignacio Fernando Hall, Elena Butoi, Paolo Magni, Junxi Wu, Susana Novella, Luke F. Gamon, Michael J. Davies, Andrea Caporali, Fernando de la Cuesta, Tijana Mitić. Unravelling molecular mechanisms in atherosclerosis using cellular models and omics technologies. Vascular Pharmacology, Volume 158, 107452, 2025. doi: 10.1016/j.vph.2024.107452 (Q1-ranked).

Laura Toma, Mariana Deleanu, Gabriela M. Sanda, Teodora Barbălată, Loredan S. Niculescu, Anca V. Sima, Camelia S. Stancu. Bioactive Compounds Formulated in Phytosomes Administered as Complementary Therapy for Metabolic Disorders. International Journal of Molecular Sciences 25(8): 4162, 2024.doi: 10.3390/ijms25084162 (Q1-ranked).

Submitted manuscripts

Laura Toma, Teodora Barbălată, Jessica I. C. Hărătău, Gabriela M. Sanda, Elena V. Fuior, Ioana M. Fenyo, Loredan S. Niculescu, Shlomo Sasson, Anca V. Sima, Camelia S. Stancu. Overexpression of endogenous apolipoprotein A1 and paraoxonase 1 genes in hepatocytes by CRISPR/dCas9 technology to impede atherosclerosis progression. Submitted at Molecular Biomedicine (Q1 ranked).
Laura M. Dăian, Andrei M. Văcaru, Gabriela Tanko, Elena M. Lambă, Oana A. M Mardare, Luiza Ghila, Simona Chera, Ana-Maria Văcaru. β-cell adaptation to increased insulin demand is a swift and dynamic process orchestrated by unfolded protein response. Submitted at Cell Communication and Signaling – Spinger Nature (Q1 ranked).
Cristina M. Mihai, Mirel A. Popa. Sex hormones in cardiovascular development: methodological standards for human cardiac organoid research. Submitted at FEBS Letters (Q1 ranked).

Communications at scientific meetings

International Conference Vascular Medicine and Atherosclerosis Congress 2026

Köln/Cologne, Germany, 5-7 February 2026

Oral communication: Teodora Barbălată, Gabriela M. Sanda, Laura Toma, Jessica I.C. Hărătau (Ciobanu), Elena V. Fuior, Mădălina I. Fenyo, Loredan S. Niculescu, Shlomo Sasson, Anca V. Sima, Camelia S. Stancu. Hepatic CRISPR/dCas9-mediated overexpression of apolipoprotein A1 and paraoxonase 1 reduces the atherosclerotic burden in apoE deficient mice.
Poster communication: Jessica I. C. Hărătău (Ciobanu), Loredan S. Niculescu, Elena V. Fuior, Anca V. Sima, Shlomo Sasson, Camelia S. Stancu, Laura Toma. CRISPR/dCas9 long-term transcriptional activation of apolipoprotein A1 and paraoxonase 1 in hepatocytes to ameliorate endothelial cell dysfunction.

The 46^th Annual Scientific Simposium of ICBP-NS „Progresses in translational research of cardiovascular system for heart health”

Bucharest, Romania, 17-18 December 2025

Poster Communication: Gabriela M. Sanda, Laura Toma, Jessica Ciobanu, Teodora Barbălată, Elena V. Fuior, Mădălina I. Fenyo, Loredan S. Niculescu, Anca V. Sima, Camelia S. Stancu. Transcriptional activation of endogenous glutathione peroxidases by CRISPR/dCas9 technology to improve the antioxidant protection of enterocytes in vitro and in vivo.

International Conference: 42^nd Annual Scientific Session of the Romanian Society for Cell Biology

Bucharest, Romania, 20-21 November 2025

Oral presentation - Young Scientists Session: Laura Toma^#, Teodora Barbălată^#, Jessica I.C. Ciobanu, Gabriela M. Sanda, Elena V. Fuior, Mădălina I. Fenyo, Loredan S. Niculescu, Anca V. Sima, Camelia S. Stancu. Overexpression of endogenous apolipoprotein A-I and paraoxonase 1 genes in the liver of apoe^-/- mice by CRISPR/dCas9; an approach to impede atherosclerosis progression.
Short Communications Session (e-Poster): Laura M. Dăian, Andrei M. Văcaru, Elena M. Lambă, Oana A.-M. Mardare, Ana-Maria Văcaru. Preliminary Dynamics of β-Cell Adjustment to Reduced Mass and Diet-Related Stress
Short Communications Session (e-Poster): Elena Mirela Lambă, Oana-Ana-Maria Mardare, Laura Maria Daian, Andrei Mircea Văcaru, Ana-Maria Văcaru. Sweet Habits: Shaping Pancreatic β-cell Adaptation

International Conference: Molecular Biology - Current Aspects and Prospects

Cluj-Napoca, Romania, 4-7 November 2025

Oral presentation: Jessica I.C. Ciobanu, Teodora Barbalata, Laura Toma, Elena V. Fuior, Madalina I. Fenyo, Anca V. Sima, Camelia S. Stancu. CRISPR/dCas9 Long-Term Transcriptional Activation of Hepatic Alipoprotein A-I And Paraoxonase 1 to Improve HDL Function.

The 61^st Annual Meeting of European Association for the Study of Diabetes (EASD)

Wien, Austria, 15-19 September 2025

Short oral presentation: Laura Toma, Teodora Barbălată, Jessica I.C. Ciobanu, Gabriela M. Sanda, Elena V. Fuior, Mădălina I. Fenyo, Loredan S. Niculescu, Anca V. Sima, Camelia S. Stancu. Transcriptional activation of endogenous paraoxonase 2 by CRISPR/dCas9 technology to improve the function of hepatocytes under pro-diabetic conditions; an in vitro and in vivo strategy.

The 49^th Federation of European Biochemical Societies (FEBS) 2025 Congress

Istanbul, Turkey, 5-9 July 2025

Poster communication: Teodora Barbălată, Oriana E. Moraru, Gabriela M. Sanda, Laura Toma, Camelia S. Stancu, Anca V. Sima, Loredan S. Niculescu. Circulating non-coding RNAs as promising biomarkers for atherosclerosis.
Poster communication: Gabriela M. Sanda, Laura Toma, Jessica I.C. Ciobanu, Teodora Barbalata, Elena V. Fuior, Madalina I. Fenyo , Loredan S. Niculescu, Anca V. Sima, Camelia S. Stancu. Transcriptional activation of endogenous glutathione peroxidases by CRISPR/dCas9 technology to improve the antioxidant protection of enterocytes in vitro and in vivo.

Atherosclerosis - Gordon Research Conference

"Genetics, Pathophysiology, and Translation"

Castelldefels, Spania, 22 - 27 June 2025

Poster communication: Laura Toma, Teodora Barbălată, Jessica I.C. Ciobanu, Gabriela M. Sanda, Elena V. Fuior, Madalina I. Fenyo, Loredan S. Niculescu, Anca V. Sima, Camelia S. Stancu. Transcriptional activation of endogenous apolipoprotein A-I and paraoxonase 1 by CRISPR/dCas9 technology to improve the function of high-density lipoproteins.

International Conference: The 41^st Annual Scientific Session of the Romanian Society for Cell Biology (RSCB)

Targu Mures, Romania, 11-13 December 2024

Oral communication in PhD students Session: Jessica I.C. Ciobanu, Laura Toma, Elena V. Fuior, Gabriela M. Sanda, Anca V. Sima, Camelia S. Stancu. CRISPR/dCas9 long-term transcriptional activation of hepatic key proteins to improve HDL function.
Poster communication: Teodora Barbălată, Orina Moraru, Gabriela M. Sanda, Laura Toma, Camelia S. Stancu, Anca V. Sima, Loredan S. Niculescu. Non-coding RNAs as novel biomarkers in atherosclerosis.

The XXXVII National Chemistry Conference CNCHIM 2024, Targoviste, Romania, 25-27 September 2024

Poster communication: Mariana Deleanu, Laura Toma, Gabriela Sanda, Anca V. Sima, Justinian Tomescu, Georgeta Alexandru, Camelia S. Stancu. Preparation and characterization of hawthorn berries and grapes skin extracts; antioxidant and anti-inflammatory effects in endothelial cells.

Training stages and courses performed by the team members

Dr. Raluca Tutuianu - 10-12 July 2023 - Summer School: Advancing skills in 3D skin and epidermal biology computer modelling of the COST action CA21108, University of Surrey, School of Chemistry and Chemical, Faculty of Engineering and Physical Sciences, Guildford, Surrey, UK

Dr. Raluca Tutuianu - 11-22 September 2023 - FELASA Accredited Course: 9th Laboratory Animal Science European Union Functions Course, Laboratory for Research of the Musculoskeletal System, School of Medicine, National & Kapodistrian Athens University, Greece

Drd. Daniela M. Ghetu - 1 September 2023 -31 May 2024 - Doctoral fellowship from Ministry of Education, H.G.118/2023 – 9-month stage and Medical Center of Leiden University, Anatomy and Embriology Department, Leiden, The Netherlands, Coordinator: dr. Karine Raymond

Dr. Teodora Barbălată and Drd. Jessica I.C. Ciobanu - 17 April -7 June 2024 - FELASA Accredited Course: 10^th International Course „Care and use of laboratory animals: mice, rats and zebrafish”, Department of Biology, University of Crete and Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete, Greece

Drd. Daniela M. Ghetu – 28 June 2025 – 4 July 2025 - 3D Skin Models Training School COST CA21108 European Network for Skin Engineering and Modeling (NETSKINMODELS), Experimental Dermatology lab, Radboud University Medical Center, The Netherlands

Dr. Raluca Tutuianu – 15 September – 15 December 2025- Visiting Ph.D. at Unit of Cell and Gene Therapies – Cell Factory Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italia; Project title: The effect of hiPSC derived small EVs on fibrotic lung organoids

Drd. Daniela-Mădălina Ghețu – 16-21 November 2025 - Training Course ”Applied In Vitro Toxicology Course”, organized by the European Society of Toxicology In Vitro (ESTIV), in collaboration with the Centre of Experimental Medicine SAS (CEM) in Bratislava, Slovakia